epihet for intra-tumoral epigenetic heterogeneity analysis and visualization

epihet for intra-tumoral epigenetic heterogeneity analysis and visualization

Blog Article

Abstract Intra-tumoral epigenetic heterogeneity is an indicator of tumor population fitness and is linked to the deregulation of transcription.However, there is no published computational tool to automate the measurement of intra-tumoral epigenetic allelic Humidifiers and Nebulizers - Nebulizers heterogeneity.We developed an R/Bioconductor package, epihet, to calculate the intra-tumoral epigenetic heterogeneity and to perform differential epigenetic heterogeneity analysis.

Furthermore, epihet can implement a biological network analysis workflow for transforming cancer-specific differential epigenetic heterogeneity loci into cancer-related biological function and clinical biomarkers.Finally, we demonstrated epihet Exfoliants utility on acute myeloid leukemia.We found statistically significant differential epigenetic heterogeneity (DEH) loci compared to normal controls and constructed co-epigenetic heterogeneity network and modules.

epihet is available at https://bioconductor.org/packages/release/bioc/html/epihet.html.